The design and development of a multicentric protocol investigating the impact of doxycycline on lymphodema

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Performing a multicentric clinical study is challenging, especially when it is a double-blind, placebo-control. Scientists from IMMIP-Bonn, Cameroon, Ghana, India, Mali, Sri Lanka, United Kingdom and United States of America, have published their study protocol, providing details on challenges faced and how they were resolved. The ongoing study, is conducted by 2 consortia,  in six sites and is funded by the German Federal Ministry of Education and Research (BmBF) https://www.gesundheitsforschung-bmbf.de/en/research-networks-for-health-innovations-in-sub-saharan-africa-7694.php and United States Agency for International Development (USAID) (grant # AID-OAA-G-14-00008).

Publication Title: The design and development of a multicentric protocol to investigate the impact of adjunctive doxycycline on the management of peripheral lymphoedema caused by lymphatic filariasis and podoconiosis

Abstract

As new lymphatic filariasis infections are eliminated through mass chemotherapy, previously affected individuals are left with the sequellae, especially chronic progressive lymphoedema. Currently this is managed by careful attention to limb hygiene to prevent infection. Studies over the past 15 years have suggested that the incorporation
of doxycycline treatment may arrest or even reverse progression of lymphoedema. Most of this work has been observational or based on small studies, and if this intervention is effective, studies need to be conducted on a larger scale and under diverse geographical and social conditions before it can be incorporated into treatment policy.

The article, published in Parasites and Vectors  can be accessed here,  or downloaded as a PDF document below.

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Horton_et_al-2020-Parasites_&_Vectors.pdf1.01 MB
Date: 
Thursday, April 2, 2020 - 17:08

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