Clinical development of two antimicrobial agents funded by Else Kröner-Fresenius Foundation

Production of Corallopyronin A clinical trial samples

Corallopyronin A is an antibiotic derived from marine soil bacteria by biotechnological means. The spectrum of activity of the antibiotic, which was developed under the leadership of Prof. Dr Achim Hörauf at the University Hospital Bonn, Prof. Dr Karl Wagner at the University of Bonn and Prof. Dr Marc Stadler at the Helmholtz Centre for Infection Research in Braunschweig, includes tropical worm diseases and multi-resistant bacteria. For corallopyronin A to be effective as a capsule, it needs to be embedded in edible polymers that improve solubility. Clinical trials require certified manufacturing, which is now made possible by the ForTra grant.

"For a project as large as the development of an antibiotic, there has to be collaboration between different funding agencies, as the financial volumes required are usually beyond the capacity of individual funders. We are very pleased that ForTra gGmbH, with its programmatic orientation, is filling a gap in this funding call and enabling us to proceed with the project," emphasises Prof. Hörauf.

Continue to full DZIF press release

Photo © Universität Bonn/Prof. Dr. Karl Wagner