Prof. Dr. Marc Hübner                  
DZIF Professor für Translationale Mikrobiologie

Marc.Huebner @ ukbonn.de
 ©UKB /J. F. Saba

Filarien können schwerwiegende Erkrankungen wie die lymphatische Filariose (Elefantiasis) und die Onchozerkose (Flussblindheit) im Menschen auslösen. Dabei modulieren Filarien generell das Immunsystem ihrer Wirte, um die Entstehung von Pathologien zu vermeiden und ihr langfristiges Überleben im Wirt zu erreichen. Bislang gibt es weder Therapien, die innerhalb von 1-2 Wochen Behandlungszeit makrofilarizid wirken, d.h. die adulten Filarien abtöten können, noch eine Vakzine für Filariosen. Im Rahmen meiner DZIF Professur soll die Translation von Grundlagen- und präklinischer Forschung in humane Studien erfolgen, um neue Therapien für Vernachlässigte Tropenerkrankungen (NTDs) zu identifizieren.  

 

In meinem Labor bearbeiten wir folgende Aspekte der Filariose:

  1. Präklinische Testung zur Identifizierung neuer makrofilarizider Substanzen im Litomosoides sigmodontis Nagetiermodell für Filariosen und Unterstützung von klinischen Studien in Kollaboration mit Partnern aus der Industrie und non-profit Organisationen.   
  2. Protektive Immunantworten gegen Filarien mit besonderem Fokus auf Eosinophile und Neutrophile und dem Einfluss von extrazellulären DNA Netzen (ETosis). Zudem arbeiten wir daran Vakzineantworten zu optimieren und die zugrundeliegenden Immunantworten besser zu verstehen. Diese Untersuchungen werden im L. sigmodontis Nagetiermodell mit immundefizienten Mäusen sowie in vitro Kulturen von murinen und humanen Zellen durchgeführt.

  3. Immunmodulation durch Filarien und deren protektiver Effekt auf metabolische Erkrankungen wie die Diät-induzierte Insulinresistenz. Dies erfolgt sowohl im L. sigmodontis Mausmodell als auch in einer humanen Studie mit Filariosepatienten in Kamerun.

 

Finanzierung:

  • Deutsche Forschungsgemeinschaft (DFG), German African Project: Impact of human filarial infections on the metabolic and immunological profile
  • Deutsche Forschungsgemeinschaft, Excellence Cluster ImmunoSensation2 : Filarial immunomodulation
  • Drugs for Neglected Diseases Initiative (DNDi) : In vivo and in vitro testing of potential macrofilaricidal drug candidates
  • Deutsches Zentrum für Infektionsforschung (DZIF): DZIF Professorship - pre-clinical and clinical identification of novel treatments for NTDs
  • Elanco: In vivo testing of drug candidates in the L. sigmodontis model
  • European Commission Horizon 2020: HELP - Helminth Elimination Platform
  • Manchot Stiftung: Scholarship on ILCs for Julia Reichwald

Mitarbeiter

Dr. rer. nat. Alexandra Ehrens
Postdoctoral fellow,
Tel: 0228 287 19155

Dr. Indulekha Karunakaran
Postdoctoral fellow
Tel: 0228 28719169
 ©UKB /J. F. Saba

MSc. Frederic Risch
Ph.D. Student
Tel: 0228 287 16312
 ©UKB /J. F. Saba

MSc. Johanna Scheunemann,
Ph.D. Student,
Tel: 0228 28716312

MSc Julia Reichwald

Ph.D. Student
Tel: 0228 287 16312
 ©UKB /J. F. Saba

MSc Benjamin Lenz
PhD Student
Tel: 0228 28719155

MSc Anna-Lena Neumann
Ph.D. Student
Tel: 0228 287 19169
 

Martina Fendler
MTA
Tel: 0228 287 16111

©UKB /J. F. Saba

Marianne Koschel

MTA

Tel: 0228 287 19155
 

Wiebke Stamminger
MTA
Tel: 0228 28719155

    2021

  1. Ehrens, A; Lenz, B; Neumann, AL; Giarrizzo, S; Reichwald, JJ; Frohberger, SJ; Stamminger, W; Buerfent, BC; Fercoq, F; Martin, C; Kulke, D; Hoerauf, A; Hübner, MP:
    Microfilariae Trigger Eosinophil Extracellular DNA Traps in a Dectin-1-Dependent Manner.
    Cell Rep 34(2), 2021, 108621. doi: 10.1016/j.celrep.2020.108621

  2. Ehrens, A; Rüdiger, N; Heepmann, L; Linnemann, L; Hartmann, W; Hübner, MP; Breloer, M:
    Eosinophils and Neutrophils Eliminate Migrating Larvae at the Site of Infection in the Context of Extracellular DNA Trap Formation.
    Front Immunol 12, 2021, 715766. doi: 10.3389/fimmu.2021.715766

  3. Gandjui, NVT; Njouendou, AJ; Gemeg, EN; Fombad, FF; Ritter, M; Kien, CA; Chunda, VC; Fru, J; Esum, ME; Hübner, MP; Enyong, PA; Hoerauf, A; Wanji, S:
    Establishment of an in vitro culture system to study the developmental biology of Onchocerca volvulus with implications for anti-Onchocerca drug discovery and screening.
    PLoS Negl Trop Dis 15(2), 2021, e0008513. doi: 10.1371/journal.pntd.0008513

  4. Hübner, MP; Townson, S; Gokool, S; Tagboto, S; Maclean, MJ; Verocai, GG; Wolstenholme, AJ; Frohberger, SJ; Hoerauf, A; Specht, S; Scandale, I; Harder, A; Glenschek-Sieberth, M; Hahnel, SR; Kulke, D:
    Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside.
    Int J Parasitol Drugs Drug Resist 17, 2021, 27-35. doi: 10.1016/j.ijpddr.2021.07.005

  5. Krücken, J; Holden-Dye, L; Keiser, J; Prichard, RK; Townson, S; Makepeace, BL; Hübner, MP; Hahnel, SR; Scandale, I; Harder, A; Kulke, D:
    Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration.
    PLoS Pathog 17(7), 2021, e1009682. doi: 10.1371/journal.ppat.1009682

  6. Risch, F; Ritter, M; Hoerauf, A; Hübner, MP:
    Human filariasis-contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model.
    Parasitol Res , 2021. doi: 10.1007/s00436-020-07026-2

    2020

  1. Akama, T; Freund, YR; Berry, PW; Carter, DS; Easom, EE; Jarnagin, K; Lunde, CS; Plattner, JJ; Rock, F; Stefanakis, R; Fischer, C; Bulman, CA; Lim, KC; Suzuki, BM; Tricoche, N; Mansour, A; DiCosty, U; McCall, S; Carson, B; McCall, JW; McKerrow, J; Hübner, MP; Specht, S; Hoerauf, A; Lustigman, S; Sakanari, JA; Jacobs, RT:
    Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.
    ACS Infect Dis 6(2), 2020, 173-179. doi: 10.1021/acsinfecdis.9b00396

  2. Alvar, J; Alves, F; Bucheton, B; Burrows, L; Büscher, P; Carrillo, E; Felger, I; Hübner, MP; Moreno, J; Pinazo, MJ; Ribeiro, I; Sosa-Estani, S; Specht, S; Tarral, A; Wourgaft, NS; Bilbe, G:
    Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases.
    Semin Immunopathol 42(3), 2020, 231-246. doi: 10.1007/s00281-020-00796-y

  3. Ehrens, A; Lunde, CS; Jacobs, RT; Struever, D; Koschel, M; Frohberger, SJ; Lenz, F; Fendler, M; Turner, JD; Ward, SA; Taylor, MJ; Freund, YR; Stefanakis, R; Easom, E; Li, X; Plattner, JJ; Hoerauf, A; Hübner, MP:
    In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
    PLoS Negl Trop Dis 14(1), 2020, e0007957. doi: 10.1371/journal.pntd.0007957

  4. Frohberger, SJ; Fercoq, F; Neumann, AL; Surendar, J; Stamminger, W; Ehrens, A; Karunakaran, I; Remion, E; Vogl, T; Hoerauf, A; Martin, C; Hübner, MP:
    S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis.
    PLoS Negl Trop Dis 14(2), 2020, e0008119. doi: 10.1371/journal.pntd.0008119

  5. Hübner, MP; Gunderson, E; Vogel, I; Bulman, CA; Lim, KC; Koschel, M; Ehrens, A; Frohberger, SJ; Fendler, M; Tricoche, N; Voronin, D; Steven, A; Chi, V; Bakowski, MA; Woods, AK; Petrassi, HM; McNamara, CW; Beerntsen, B; Chappell, L; Sullivan, W; Taylor, MJ; Turner, JD; Hoerauf, A; Lustigman, S; Sakanari, JA:
    Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models.
    Int J Parasitol Drugs Drug Resist 12, 2020, 18-27. doi: 10.1016/j.ijpddr.2019.12.001

  6. Hübner, MP; Martin, C; Specht, S; Koschel, M; Dubben, B; Frohberger, SJ; Ehrens, A; Fendler, M; Struever, D; Mitre, E; Vallarino-Lhermitte, N; Gokool, S; Lustigman, S; Schneider, M; Townson, S; Hoerauf, A; Scandale, I:
    Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
    PLoS Negl Trop Dis 14(7), 2020, e0008427. doi: 10.1371/journal.pntd.0008427

  7. Krome, AK; Becker, T; Kehraus, S; Schiefer, A; Steinebach, C; Aden, T; Frohberger, SJ; López Mármol, Á; Kapote, D; Jansen, R; Chaverra-Muñoz, L; Hübner, MP; Pfarr, K; Hesterkamp, T; Stadler, M; Gütschow, M; König, GM; Hoerauf, A; Wagner, KG:
    Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A.
    Pharmaceutics 12(11), 2020. doi: 10.3390/pharmaceutics12111105

  8. Kuehlwein, JM; Borsche, M; Korir, PJ; Risch, F; Mueller, AK; Hübner, MP; Hildner, K; Hoerauf, A; Dunay, IR; Schumak, B:
    Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation.
    Immunology 159(2), 2020, 193-204. doi: 10.1111/imm.13137

  9. Ostendorf, T; Zillinger, T; Andryka, K; Schlee-Guimaraes, TM; Schmitz, S; Marx, S; Bayrak, K; Linke, R; Salgert, S; Wegner, J; Grasser, T; Bauersachs, S; Soltesz, L; Hübner, MP; Nastaly, M; Coch, C; Kettwig, M; Roehl, I; Henneke, M; Hoerauf, A; Barchet, W; Gärtner, J; Schlee, M; Hartmann, G; Bartok, E:
    Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.
    Immunity 52(4), 2020, 591-605.e6. doi: 10.1016/j.immuni.2020.03.009

  10. Schiefer, A; Hübner, MP; Krome, A; Lämmer, C; Ehrens, A; Aden, T; Koschel, M; Neufeld, H; Chaverra-Muñoz, L; Jansen, R; Kehraus, S; König, GM; Pogorevc, D; Müller, R; Stadler, M; Hüttel, S; Hesterkamp, T; Wagner, K; Pfarr, K; Hoerauf, A:
    Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections.
    PLoS Negl Trop Dis 14(12), 2020, e0008930. doi: 10.1371/journal.pntd.0008930

  11. Surendar, J; Karunakaran, I; Frohberger, SJ; Koschel, M; Hoerauf, A; Hübner, MP:
    Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice.
    Front Endocrinol (Lausanne) 11, 2020, 257. doi: 10.3389/fendo.2020.00257

    2019

  1. Bakowski, MA; Shiroodi, RK; Liu, R; Olejniczak, J; Yang, B; Gagaring, K; Guo, H; White, PM; Chappell, L; Debec, A; Landmann, F; Dubben, B; Lenz, F; Struever, D; Ehrens, A; Frohberger, SJ; Sjoberg, H; Pionnier, N; Murphy, E; Archer, J; Steven, A; Chunda, VC; Fombad, FF; Chounna, PW; Njouendou, AJ; Metuge, HM; Ndzeshang, BL; Gandjui, NV; Akumtoh, DN; Kwenti, TDB; Woods, AK; Joseph, SB; Hull, MV; Xiong, W; Kuhen, KL; Taylor, MJ; Wanji, S; Turner, JD; Hübner, MP; Hoerauf, A; Chatterjee, AK; Roland, J; Tremblay, MS; Schultz, PG; Sullivan, W; Chu, XJ; Petrassi, HM; McNamara, CW:
    Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.
    Sci Transl Med 11(491), 2019. doi: 10.1126/scitranslmed.aav3523

  2. Buerfent, BC; Ajendra, J; Stamminger, W; Gondorf, F; Hoerauf, A; Hübner, MP:
    TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection.
    GMS Infect Dis 7, 2019, Doc04. doi: 10.3205/id000044

  3. Buerfent, BC; Gölz, L; Hofmann, A; Rühl, H; Stamminger, W; Fricker, N; Hess, T; Oldenburg, J; Nöthen, MM; Schumacher, J; Hübner, MP; Hoerauf, A:
    Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels.
    Sci Rep 9(1), 2019, 2562. doi: 10.1038/s41598-019-38985-x

  4. Fercoq, F; Remion, E; Frohberger, SJ; Vallarino-Lhermitte, N; Hoerauf, A; Le Quesne, J; Landmann, F; Hübner, MP; Carlin, LM; Martin, C:
    IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation.
    PLoS Negl Trop Dis 13(8), 2019, e0007691. doi: 10.1371/journal.pntd.0007691

  5. Frohberger, SJ; Ajendra, J; Surendar, J; Stamminger, W; Ehrens, A; Buerfent, BC; Gentil, K; Hoerauf, A; Hübner, MP:
    Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils.
    Parasit Vectors 12(1), 2019, 248. doi: 10.1186/s13071-019-3502-z

  6. Hong, WD; Benayoud, F; Nixon, GL; Ford, L; Johnston, KL; Clare, RH; Cassidy, A; Cook, DAN; Siu, A; Shiotani, M; Webborn, PJH; Kavanagh, S; Aljayyoussi, G; Murphy, E; Steven, A; Archer, J; Struever, D; Frohberger, SJ; Ehrens, A; Hübner, MP; Hoerauf, A; Roberts, AP; Hubbard, ATM; Tate, EW; Serwa, RA; Leung, SC; Qie, L; Berry, NG; Gusovsky, F; Hemingway, J; Turner, JD; Taylor, MJ; Ward, SA; O'Neill, PM:
    AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis.
    Proc Natl Acad Sci U S A 116(4), 2019, 1414-1419. doi: 10.1073/pnas.1816585116

  7. Hübner, MP; Ehrens, A; Koschel, M; Dubben, B; Lenz, F; Frohberger, SJ; Specht, S; Quirynen, L; Lachau-Durand, S; Tekle, F; Baeten, B; Engelen, M; Mackenzie, CD; Hoerauf, A:
    Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
    PLoS Negl Trop Dis 13(1), 2019, e0006320. doi: 10.1371/journal.pntd.0006320

  8. Hübner, MP; Koschel, M; Struever, D; Nikolov, V; Frohberger, SJ; Ehrens, A; Fendler, M; Johannes, I; von Geldern, TW; Marsh, K; Turner, JD; Taylor, MJ; Ward, SA; Pfarr, K; Kempf, DJ; Hoerauf, A:
    In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.
    PLoS Negl Trop Dis 13(8), 2019, e0007636. doi: 10.1371/journal.pntd.0007636

  9. Jacobs, RT; Lunde, CS; Freund, YR; Hernandez, V; Li, X; Xia, Y; Carter, DS; Berry, PW; Halladay, J; Rock, F; Stefanakis, R; Easom, E; Plattner, JJ; Ford, L; Johnston, KL; Cook, DAN; Clare, R; Cassidy, A; Myhill, L; Tyrer, H; Gamble, J; Guimaraes, AF; Steven, A; Lenz, F; Ehrens, A; Frohberger, SJ; Koschel, M; Hoerauf, A; Hübner, MP; McNamara, CW; Bakowski, MA; Turner, JD; Taylor, MJ; Ward, SA:
    Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
    J Med Chem 62(5), 2019, 2521-2540. doi: 10.1021/acs.jmedchem.8b01854

  10. Karunakaran, I; Alam, S; Jayagopi, S; Frohberger, SJ; Hansen, JN; Kuehlwein, J; Hölbling, BV; Schumak, B; Hübner, MP; Gräler, MH; Halle, A; van Echten-Deckert, G:
    Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation.
    Glia 67(10), 2019, 1859-1872. doi: 10.1002/glia.23663

  11. Kuehn, C; Tauchi, M; Furtmair, R; Urschel, K; Raaz-Schrauder, D; Neumann, AL; Frohberger, SJ; Hoerauf, A; Regus, S; Lang, W; Sagban, TA; Stumpfe, FM; Achenbach, S; Hübner, MP; Dietel, B:
    Filarial extract of induces a type 2 immune response and attenuates plaque development in hyperlipidemic ApoE-knockout mice.
    FASEB J 33(5), 2019, 6497-6513. doi: 10.1096/fj.201800947RR

  12. Safi, S; Frommholz, D; Reimann, S; Götz, W; Bourauel, C; Neumann, AL; Hoerauf, A; Ilges, H; Safi, AF; Jäger, A; Hübner, MP; Gölz, L:
    Comparative study on serum-induced arthritis in the temporomandibular and limb joint of mice.
    Int J Rheum Dis 22(4), 2019, 636-645. doi: 10.1111/1756-185X.13486

  13. Surendar, J; Frohberger, SJ; Karunakaran, I; Schmitt, V; Stamminger, W; Neumann, AL; Wilhelm, C; Hoerauf, A; Hübner, MP:
    Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis.
    Front Immunol 10, 2019, 2555. doi: 10.3389/fimmu.2019.02555

  14. Taylor, MJ; von Geldern, TW; Ford, L; Hübner, MP; Marsh, K; Johnston, KL; Sjoberg, HT; Specht, S; Pionnier, N; Tyrer, HE; Clare, RH; Cook, DAN; Murphy, E; Steven, A; Archer, J; Bloemker, D; Lenz, F; Koschel, M; Ehrens, A; Metuge, HM; Chunda, VC; Ndongmo Chounna, PW; Njouendou, AJ; Fombad, FF; Carr, R; Morton, HE; Aljayyoussi, G; Hoerauf, A; Wanji, S; Kempf, DJ; Turner, JD; Ward, SA:
    Preclinical development of an oral anti- macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.
    Sci Transl Med 11(483), 2019. doi: 10.1126/scitranslmed.aau2086

  15. von Geldern, TW; Morton, HE; Clark, RF; Brown, BS; Johnston, KL; Ford, L; Specht, S; Carr, RA; Stolarik, DF; Ma, J; Rieser, MJ; Struever, D; Frohberger, SJ; Koschel, M; Ehrens, A; Turner, JD; Hübner, MP; Hoerauf, A; Taylor, MJ; Ward, SA; Marsh, K; Kempf, DJ:
    Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
    PLoS Negl Trop Dis 13(2), 2019, e0007159. doi: 10.1371/journal.pntd.0007159

    2018

  1. Muhsin, M; Ajendra, J; Gentil, K; Berbudi, A; Neumann, AL; Klaas, L; Schmidt, KE; Hoerauf, A; Hübner, MP:
    IL-6 is required for protective immune responses against early filarial infection.
    Int J Parasitol 48(12), 2018, 925-935. doi: 10.1016/j.ijpara.2018.05.011

  2. Specht, S; Pfarr, KM; Arriens, S; Hübner, MP; Klarmann-Schulz, U; Koschel, M; Sternberg, S; Martin, C; Ford, L; Taylor, MJ; Hoerauf, A:
    Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.
    PLoS Negl Trop Dis 12(1), 2018, e0006116. doi: 10.1371/journal.pntd.0006116

    2017

  1. Surendar, J; Indulekha, K; Hoerauf, A; Hübner, MP:
    Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?
    Parasite Immunol 39(5), 2017. doi: 10.1111/pim.12401

    2016

  1. Ajendra, J; Berbudi, A; Hoerauf, A; Hübner, MP:
    Combination of worm antigen and proinsulin prevents type 1 diabetes in NOD mice after the onset of insulitis.
    Clin Immunol 164, 2016, 119-22. doi: 10.1016/j.clim.2016.02.005

  2. Ajendra, J; Specht, S; Ziewer, S; Schiefer, A; Pfarr, K; Parčina, M; Kufer, TA; Hoerauf, A; Hübner, MP:
    NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae.
    Sci Rep 6, 2016, 39648. doi: 10.1038/srep39648

  3. Berbudi, A; Ajendra, J; Wardani, AP; Hoerauf, A; Hübner, MP:
    Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes.
    Diabetes Metab Res Rev 32(3), 2016, 238-50. doi: 10.1002/dmrr.2673

  4. Berbudi, A; Surendar, J; Ajendra, J; Gondorf, F; Schmidt, D; Neumann, AL; Wardani, AP; Layland, LE; Hoffmann, LS; Pfeifer, A; Hoerauf, A; Hübner, MP:
    Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice.
    J Innate Immun 8(6), 2016, 601-616. doi: 10.1159/000448401

  5. Gölz, L; Buerfent, BC; Hofmann, A; Hübner, MP; Rühl, H; Fricker, N; Schmidt, D; Johannes, O; Jepsen, S; Deschner, J; Hoerauf, A; Nöthen, MM; Schumacher, J; Jäger, A:
    Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases.
    Innate Immun 22(1), 2016, 72-84. doi: 10.1177/1753425915616685

  6. Gölz, L; Buerfent, BC; Hofmann, A; Rühl, H; Fricker, N; Stamminger, W; Oldenburg, J; Deschner, J; Hoerauf, A; Nöthen, MM; Schumacher, J; Hübner, MP; Jäger, A:
    Genome-wide transcriptome induced by nickel in human monocytes.
    Acta Biomater 43, 2016, 369-382. doi: 10.1016/j.actbio.2016.07.047

  7. Lutz, P; Krämer, B; Kaczmarek, DJ; Hübner, MP; Langhans, B; Appenrodt, B; Lammert, F; Nattermann, J; Hoerauf, A; Strassburg, CP; Spengler, U; Nischalke, HD:
    A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.
    Dig Liver Dis 48(1), 2016, 62-8. doi: 10.1016/j.dld.2015.09.011

    2015

  1. Buerfent, BC; Gondorf, F; Wohlleber, D; Schumak, B; Hoerauf, A; Hübner, MP:
    Escherichia coli-induced immune paralysis is not exacerbated during chronic filarial infection.
    Immunology 145(1), 2015, 150-60. doi: 10.1111/imm.12435

  2. Fox, EM; Morris, CP; Hübner, MP; Mitre, E:
    Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms.
    PLoS Negl Trop Dis 9(7), 2015, e0003932. doi: 10.1371/journal.pntd.0003932

  3. Gondorf, F; Berbudi, A; Buerfent, BC; Ajendra, J; Bloemker, D; Specht, S; Schmidt, D; Neumann, AL; Layland, LE; Hoerauf, A; Hübner, MP:
    Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages.
    PLoS Pathog 11(1), 2015, e1004616. doi: 10.1371/journal.ppat.1004616

  4. Layland, LE; Ajendra, J; Ritter, M; Wiszniewsky, A; Hoerauf, A; Hübner, MP:
    Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses.
    Parasit Vectors 8, 2015, 396. doi: 10.1186/s13071-015-1011-2

    2014

  1. Ajendra, J; Specht, S; Neumann, AL; Gondorf, F; Schmidt, D; Gentil, K; Hoffmann, WH; Taylor, MJ; Hoerauf, A; Hübner, MP:
    ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance.
    PLoS One 9(3), 2014, e93072. doi: 10.1371/journal.pone.0093072

  2. Gentil, K; Lentz, CS; Rai, R; Muhsin, M; Kamath, AD; Mutluer, O; Specht, S; Hübner, MP; Hoerauf, A:
    Eotaxin-1 is involved in parasite clearance during chronic filarial infection.
    Parasite Immunol 36(2), 2014, 60-77. doi: 10.1111/pim.12079

    2013

  1. Hübner, MP; Layland, LE; Hoerauf, A:
    Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour?
    Pathog Dis 69(2), 2013, 127-41. doi: 10.1111/2049-632X.12080